Epidemiology of AMI and unmet medical need
What is a heart attack?
A myocardial infarction, also known as a “heart attack”, is the destruction of a more or less extensive area of the heart muscle. It is mostly the consequence of the obstruction of a coronary artery when cholesterol (fat) accumulates in the form of atheromatous plaques on its walls.
A myocardial infarction occurs when a plaque breaks off, moves and is trapped in a coronary artery. A blood clot forms around the plaque and interrupts the blood supply, depriving the heart of oxygen.
An average 80,000 people have a heart attack every year in France.
Approximately 12,000 people die each year as a result of a myocardial infarction:
- One person in 10 dies within an hour,
- Then the mortality rate is 15% in the first year and continues to fall as therapeutic progress, the speed and quality of intervention by rescue teams(provided they are called quickly) are more efficient and interventional cardiology units availability is increased.
Unmet medical needs: Post-AMI heart failure
Regenerative Medicine is a new model for transforming medicine to provide a solution. Today despite availability of small molecules to treat symptoms of heart failure there is still huge unmet medical needs.
Blocked artery causes Acute Myocardial Infarction (AMI) and damages to the heart muscle (loss of muscle cells).
Loss of cells reduces heart contractility and leads to heart failure